Inicio Estudios Prevalencia y factores de riesgo para infecciones del tracto urinario de inicio en la comunidad causadas por Escherichia coli productor de betalactamasas de espectro extendido en Colombia [Prevalence and risk factors for extended-spectrum β-lactamase-prod

Prevalencia y factores de riesgo para infecciones del tracto urinario de inicio en la comunidad causadas por Escherichia coli productor de betalactamasas de espectro extendido en Colombia [Prevalence and risk factors for extended-spectrum β-lactamase-prod

Fecha de publicación: 
Jueves, Julio 22, 2021
Descripción: 

"Introduction: Urinary tract infections (UTI) are common in the community. However, information of resistant isolates in this context is limited in Latin America. This study aims to determine the prevalence and risk factors associated with community-onset UTI (CO-UTI) caused by extended-spectrum β-lactamase (ESBL)-Producing Escherichia coli in Colombia.

Materials and methods: A case-control study was conducted between August and December of 2011 in three Colombian tertiary-care institutions. All patients who were admitted to the Emergency Department with a probable diagnosis of CO-UTI were invited to participate. All participating patients were asked for a urine sample. ESBL confirmatory test, antibiotic susceptibility, and molecular epidemiology were performed in these E.coli isolates (Real Time-PCR for bla genes, repetitive element palindromic PCR [rep-PCR], multilocus sequence typing [MLST] and virulence factors by PCR). Clinical and epidemiological information was recorded, and a statistical analysis was performed.

Results: Of the 2124 recruited patients, 629 had a positive urine culture, 431 of which grew E.coli; 54 were positive for ESBL, of which 29 were CTX-M-15. The majority of ESBL isolates were susceptible to ertapenem, phosphomycin and amikacin. Complicated UTI was strongly associated with ESBL-producing E.coli infections (OR=3.89; 95%CI: 1.10-13.89; P=.03). CTX-M-15-producing E.coli showed 10 different pulsotypes, 65% were PT1 or PT4, and corresponded to ST131. Most of these isolates had 8 out of the 9 analysed virulence factors.

Discussion: E.coli harbouring blaCTX-M-15 associated with ST131 is still frequent in Colombia. The presence of complicated CO-UTI increases the risk of ESBL-producing E.coli, and must be taken into account in order to provide an adequate empirical therapy."

Tipo de estudio: 
Artículo
Número de páginas: 
18
Entidad: 
Subred Integrada de Servicios de Salud Sur E.S.E.
Dependencia(s): 
Hospital Tunal
Entidades Relacionadas: 
Cali
Colombia; Fundación Clínica Valle del Lili
Colombia; Universidad ICESI
Colombia
Cleveland Clinic Foundation
Cleveland
Ohio
Estados Unidos
Centro Internacional de Entrenamiento e Investigaciones Médicas - CIDEIM
Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM
Colombia; Hospital Universitario del Valle Evaristo García «E. S. E.»
Fundación Clínica Valle del Lili
Clínica Universitaria Rafael Uribe Uribe
Laboratorio de Salud Pública
Secretaría de Salud de Bogotá
Bogotá
Título Publicación : 
Enferm Infecc Microbiol Clin
Fuente de financiación: 
"M.V. Villegas ha recibido apoyos de investigación de Merck Sharp & Dohme, Merck Colombia, Janssen-Cilag SA, Pfizer SA y AstraZeneca Colombia SA. Ninguno de los patrocinadores tuvo injerencia en el diseño, la recolección de datos, el análisis, la decisión
Fuente de información: 
"aislamientos de E. coli obtenidos a partir de muestras donde se realizó el diagnóstico de ITU-IC. "
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